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Louisville
21C Museum Hotel Louisville
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75 photos
21C Museum Hotel Louisville Exterior photo The photo shows a sunny street scene in a city, featuring a prominent golden statue of a muscular male figure, likely a depiction of the Greek god Hercules or a similar mythological character. The statue stands on a light-colored pedestal in the midd21C Museum Hotel Louisville Exterior photo This is a professionally taken photo set in what appears to be a well-stocked bar or liquor store environment. A young woman with medium-brown, shoulder-length hair and a warm smile is the central focus, standing behind a polished bar counter. She i21C Museum Hotel Louisville Exterior photo This is a photograph that captures an unusual display in what appears to be a restaurant or upscale dining area. The most striking element is a large, dramatic sculpture or taxidermied display of a tiger, which hangs prominently on the wall. The tig

Welcome to 21C Museum Hotel Louisville – Louisville

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up to 10%
lower than Booking.com
Check rooms and rates
From$209 /night
Check-in
04Jul
Check-out
05Jul
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, 40202
-
Next to the Waterfront Park
Great
8.8
9.3
/10
4.6
4.5
/5

Loved by 21C Museum Hotel Louisville guests

Spacious room
Amazing staff
Clean hotel
Wonderful museum
Comfortable ambiance
"The hotel has an art gallery in it with some truly top notch artworks on display."
Karen B from United States
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"We spent the evening exploring the art, including in the hallways, the elevators and the public bathrooms."
lovetravelfoodwine from United States
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"One of a kind experience with very interesting art all around and best bourbon tasting bar on Main street!"
Bart from United States
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"My family loved the thought-provoking art and the hotel's calming atmosphere."
GlamperGirl from United States
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"Best of all you are right on Whiskey Row so within walking distance of some great bourbon distilleries."
Juja80301
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4-star art-infused hotel in downtown Louisville with immersive experiences

Rooms & Suites

21C Museum Hotel Louisville offers uniquely designed guest rooms that pay homage to the historical bourbon and tobacco warehouses. The immersive artist suite, Asleep in The Cyclone, features a fully-functional hotel room with artist-designed components and a record player. Atrium Suites provide spacious living with king-sized beds, and Corner Suites include large windows overlooking Main Street and the Ohio River.

Dining

Proof on Main serves southern and Appalachian-inspired cuisine, showcasing local ingredients and flavors. The venue also features a well-traveled bar that includes the 21c Selects Private Barrel Program, recognized as one of the best bourbon bars in the country. Guests can enjoy craft drinks at the restaurant's lounge, perfect for cocktail enthusiasts.

Wellness

The Spa at 21c provides a comprehensive wellness experience with an on-site sauna and steam room. Multiple massage treatments are offered, including Swedish and deep tissue, to enhance relaxation and recovery. Access to the spa facilities is included with all treatments.

Location

Located on the historic Museum Row in downtown Louisville, the hotel offers an urban experience close to local attractions. Within walking distance, guests can explore the Louisville Slugger Museum & Factory and the scenic Waterfront Park. The prime location provides easy access to the Kentucky Bourbon Trail and performing arts centers.

Meetings & Events

21C Museum Hotel caters to corporate gatherings and special events with versatile gallery spaces that can be transformed as needed. Catering is provided by the acclaimed Proof on Main, ensuring a thoughtful menu for every occasion. The combination of art and creativity makes this venue a standout choice for meetings.

Highlights

Dining: Proof on Main serves southern cuisine

Rooms: Asleep in The Cyclone artist suite

Wellness: The Spa at 21c provides various massage options

Location: Steps from the Louisville Slugger Museum

Must-do experiences

  • Explore the contemporary art at the Speed Art Museum next door.
  • Enjoy a hot Brown sandwich at the historic Brown Hotel.
  • Stroll through NuLu for local boutiques and art galleries.
  • Visit the vibrant Louisville Mega Cavern for ziplining fun.
  • Taste bourbon at the Evan Williams Bourbon Experience downtown.

Select your room type

Choose from doubles, suites, or family rooms, many with breakfast, flexible cancellation, and promotional rates
    Room Balcony
    2 persons
    29 sq. feet
    1 King-size bed
    Air conditioning
    Balcony
    room details
    Deluxe King Room
    2 persons
    31 sq. feet
    1 King-size bed
    Air conditioning
    Heating
    room details
    Corner Suite
    2 persons
    61 sq. feet
    1 King-size bed
    Air conditioning
    Bathtub
    room details
Show all rooms

Price and Room Availability Calendar

Check availability and prices for your dates now!
July 2026 - July 2027
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Check-in/ Check-out

Facilities

Boutique hotels design their amenities with your relaxation and unique travel experiences in mind
Facilities: Great
8.9/10Review score

General

  • No smoking on site
  • Wi-Fi
  • Car park
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
Show more

Dining Onsite

At 21C Museum Hotel Louisville, dining becomes an artful exploration of American flavors within a modern setting. Guests can indulge in thoughtfully crafted dishes while enjoying engaging dining events that celebrate local distillers and unique culinary experiences.
21C Museum Hotel Louisville Restaurant photo The photo shows a brightly colored, unique bedroom with a striking geometric ceiling. The ceiling is constructed from numerous triangular panels, each covered in a different vibrant fabric – blues, greens, reds, oranges, yellows, pinks, and purples.
21C Museum Hotel Louisville Restaurant photo The photo shows the interior of a restaurant with a whimsical and artistic decor. The walls are a mix of exposed brick and a large, colorful wallpaper depicting a vintage floral pattern. Numerous framed pictures and artwork of varying sizes and style
21C Museum Hotel Louisville Restaurant photo The photo shows a brightly lit dining area with a whimsical and eclectic decor. The walls are covered in a busy, patterned wallpaper featuring a mix of floral and figural designs in warm, muted tones. Numerous framed artworks of varying sizes and s

Proof on Main

American
Ambiance
A modern dining experience nestled within a vibrant art-filled space, where contemporary design meets local cultural influences.
Key Offerings
Signature dishes highlight regional ingredients with innovative twists, complemented by an extensive selection of local spirits, including guest distillers. Special events like the Fork & Bottle dinner series and the annual Hog & Barrel dinner featuring Pappy Van Winkle offer unique tasting experiences.
Reservation
Reservations recommended.
Hours vary.

21C Museum Hotel Louisville Location

700 West Main Street, Louisville, 40202
Explore Louisville
Local Highlights
  • Top Attractions
  • Activities
  • Dining
  • Entertainment
Kentucky Science Center
2 minutes walking
Interactive exhibits and an IMAX theater make learning fun for all ages at this family-friendly destination.
Louisville Slugger Museum & Bat Factory
3 minutes walking
Home of the famous baseball bat, this museum offers guided tours and a glimpse into baseball history.
Muhammad Ali Center
4 minutes walking
Dedicated to the life and legacy of the boxer, this center features exhibits that showcase his humanitarian work.
KFC Yum Center
9 minutes walking
A multi-purpose arena hosting sports events and concerts, offering an exciting night out.
Waterfront Park
17 minutes walking
Spanning 85 acres along the Ohio River, this park is great for relaxation with picnic areas and scenic views.
Angel's Envy Distillery Tour
19 minutes walking
A guided tasting tour of this distillery reveals the bourbon-making process. Reservations recommended.
Biking along the Big Four Bridge
25 minutes walking
Rent a bike nearby and ride across this iconic bridge linking Kentucky and Indiana; offers stunning views.
Proof On Main
1 minute walking
A vibrant atmosphere with farm-to-table dishes and a curated selection of whiskey for a local experience.
Mussel & Burger Bar Downtown
1 minute walking
Casual, trendy spot known for gourmet burgers and fresh mussels. Great for families and groups.
Bristol Bar & Grille
2 minutes walking
Relaxed, elegant dining featuring Southern favorites and an extensive wine list; perfect for special occasions.
Fourth Street Live!
10 minutes walking
A vibrant outdoor plaza hosting live music, bars, and restaurants, making it a great nightlife destination.
KFC Yum Center Events
9 minutes walking
Catch a concert or sporting event at this venue that attracts major acts and teams throughout the year.
Getting around
  • City Centre
    Louisville 23 min  ·  1.2 mi
  • Airports
    Louisville (SDF) 18 min  ·  7.4 mi
Looking for special rates when booking early?
Explore them with us!
Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
Wireless internet is available in the entire hotel for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel

Reviews and Ratings

Real comments from travelers who have already stayed
Review score
Based on 255 verified reviews
9.1 /10
Perfect
90 %
Recommend
Breakfast
2.5/10
Cleanliness
9.2/10
Comfort
9.3/10
Facilities
8.9/10
Free WiFi
10.0/10
Location
9.4/10
Paid Wi-Fi
7.5/10
Staff
8.9/10
Value for money
8.2/10
Pros
Comfy beds
Excellent restaurant
Unique rooms
Warm welcome
Interesting art
Cons
Lacking service
Dusty room
Warm rooms
Disrespectful display
Guest reviews
based on 1899 reviews
4.5/5
based on 183 reviews
8.8/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews
Show more reviews
FAQs
About 21C Museum Hotel Louisville
What are the check-in and check-out times at 21C Museum Hotel Louisville?
Check-in is at 16:00 and check-out is by 11:00.
How far is 21C Museum Hotel Louisville from Louisville International Airport?
The hotel is 10 km from Louisville International Airport.
What nearby attractions can guests visit while staying at 21C Museum Hotel Louisville?
Nearby attractions include the Kentucky Museum of Art & Craft (1 km), Frazier International History Museum (0.5 km), and the Muhammad Ali Center (0.5 km).
Which dining options are available on-site at 21C Museum Hotel Louisville?
The hotel features an on-site restaurant, Proof on Main, that offers unique southern cuisine.
What fitness and wellness facilities are available at 21C Museum Hotel Louisville?
Guests can access a 24-hour fitness center, sauna, and a full-service spa.
What room amenities are provided at 21C Museum Hotel Louisville?
Rooms include Wi-Fi, a 50-inch flat-screen TV, air conditioning, a minibar, and an iPod docking station.
Is parking available at 21C Museum Hotel Louisville?
Valet parking is available at the hotel.
What services does 21C Museum Hotel Louisville provide for business travelers?
The hotel offers a business center and 17 meeting rooms for guests.
What types of massages can guests enjoy at the spa of 21C Museum Hotel Louisville?
Guests can choose from deep tissue and sports massages at the spa.
Does 21C Museum Hotel Louisville offer any art exhibitions?
The hotel features over 836.1 m² of exhibition space for contemporary art.
Is there a space for outdoor dining at 21C Museum Hotel Louisville?
Yes, the hotel includes an outdoor dining area.

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Check-in
04Jul
Check-out
05Jul
Rooms and Guests2 Guests, 1 Room
  • Overview
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  • Location
  • Reviews