What are the check-in and check-out times at Twentyone Hotel?
Check-in is from 15:00 and check-out is by 11:00.
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Welcome to Twentyone Hotel – Rome
349US$
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Key details
About the Hotel
Via Cola Di Rienzo 23,
Rome,
Italy,
00192,
Lazio
- Near the Vatican City
Great
8.3
8.1
3.3
3.7
Loved by Twentyone Hotel guests
"Breakfast at the top of the building ? Great."
"Rooms are very large, comfortable and have a well equipped bathroom."
"Nice rooftop breakfast area with good selection of options"
Location
Hotel Twentyone is located in the
Dining
Rooms
The hotel comprises 93 rooms, each showcasing carefully curated decor and designer furnishings.
Family-Friendly Amenities
Families will appreciate
Accessibility & Transportation
Rome's Termini train station is easily reachable via the A-line subway, providing quick access to the hotel. Additionally,
Highlights
Location: halfway between the Vatican Museums and Piazza di Spagna
Dining: Best traditional Italian dishes at Bistrò 21
Rooms: Deluxe double rooms with private terraces
Family-Friendly: Two rooms connected by a door
Must-do experiences
- Sip espresso at Sant'Eustachio for the best in Rome.
- Visit Basilica di San Clemente for layers of history.
- Stroll through the Campo de' Fiori market for fresh produce.
- Taste authentic Roman pizza at Pizzeria Da Baffetto.
- Explore the Galleria Doria Pamphilj for stunning art collections.
View all
Select your room type
Choose from doubles, suites, or family rooms, many with breakfast, flexible cancellation, and promotional rates
Twin Room
2 persons
195 sq. feet
2 Single beds
Shower
Heating
room details
Triple Room
2 persons
240 sq. feet
3 Single beds
Shower
Heating
room details
Double Room
2 persons
195 sq. feet
1 King-size bed
Shower
Heating
room details
Deluxe Twin Room
2 persons
250 sq. feet
2 Single beds
Shower
Heating
room details
Show all roomsLess
Price and Room Availability Calendar
Check availability and prices for your dates now!
Facilities
Boutique hotels design their amenities with your relaxation and unique travel experiences in mind
General
- Non-smoking rooms
- Wi-Fi
- Parking
- Safe deposit box
- 24-hour reception
- Express check-in/ -out
- No pets allowed
- Rooms/ Facilities for disabled
- Wheelchair access
- Security
- Luggage storage
- Allergy-free rooms
- Lift
- Barber shop
- Coffee shop
- Smoke detectors
- Electric vehicle charging station
- Fire extinguishers
- Key card access
Sports & Fitness
- Fitness centre
Services
- Paid airport shuttle
- Room service
- Housekeeping
- Laundry
- Dry cleaning
- Tours/Ticket assistance
- Welcome drink
Dining
- In-room breakfast
- Restaurant
- Snack bar
- Bar/ Lounge area
- Packed lunches
- Special diet menus
Business
- Fax/Photocopying
Children
- Cots
- Children's buffet
Facilities for people with disabilities
- Toilet for disabled
- Bathroom for disabled
Spa & Leisure
- Garden area
- Leisure/ TV room
Room features
- Air conditioning
- Heating
- Mini-bar
- Soundproofed rooms
- Sitting area
- Terrace
- Garden furniture
- Tea and coffee facilities
- Ironing facilities
Bathroom
- Free toiletries
- Sink
Media
- Flat-screen TV
- AM/FM alarm clock
Room decor
- Carpeted floor
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Dining Onsite
Vista is a modern dining haven at Twentyone Hotel, offering a delightful blend of international cuisines with an emphasis on traditional Roman and classic Italian flavors. The inviting atmosphere and rich buffet options create a welcoming space for leisurely meals or special gatherings.
Twentyone Hotel Location
Via Cola Di Rienzo 23,
Rome,
Italy,
00192,
Lazio
Map view
Via Cola Di Rienzo 23,
Rome,
Italy,
00192,
Lazio
City landmarks
Fountain
Trevi Fountain
1.1
mi
Church
Pantheon
5200 ft
Square
Colosseum
1.8
mi
Landmark
Piazza Navona
4400 ft
Museum
Vatican Museums
1.0
mi
Church
St. Peter's Basilica
1.1
mi
Square
Saint Peter's Square
4900 ft
Landmark
Roman Forum
1.5
mi
Landmark
Piazza di Spagna
4500 ft
Square
Spanish Steps
5000 ft
Bridge
Castel Sant'Angelo
3500 ft
Square
Piazza del Popolo
2500 ft
Square
Piazza Venezia
1.3
mi
Church
Sistine Chapel
1.1
mi
Cemetery
Altar of the Fatherland
1.4
mi
Square
Campo de' Fiori
1.1
mi
Landmark
Vatican City
1.1
mi
Museum
Borghese Gallery and Museum
1.5
mi
Bridge
St. Angelo Bridge
3600 ft
Landmark
Torre di San Giovanni
1.6
mi
Church
Church of Saint Louis the French
4500 ft
Square
Largo di Torre Argentina
1.1
mi
Church
Church of Santa Maria del Popolo
2300 ft
Zoo
Bioparco di Roma
1.3
mi
Church
Santa Maria in Trastevere
1.4
mi
Museum
Capitoline Museums
1.3
mi
Square
Piazza Barberini
1.1
mi
Museum
Museum of the Ara Pacis
3000 ft
Square
Pincian Hill
3200 ft
Church
Church of the Gesu
1.2
mi
Nearby
Bridge
Castel Sant'Angelo
3500 ft
Square
Piazza del Popolo
2500 ft
Bridge
St. Angelo Bridge
3600 ft
Church
Church of Santa Maria del Popolo
2300 ft
Church
Basilica of Sant' Agostino
3400 ft
Restaurants
Bistro' 21
100 ft
Via Cola di Rienzo 23 Hotel Twenty One
Cantieri Bistrot
300 ft
Via Cola di Rienzo 16
Le Sicilianedde
300 ft
Via Cola di Rienzo
La Pinseria Prati
300 ft
Via Lucrezio Caro 60
Pasticceria Sanzini
500 ft
Via Valadier
VINO e FOCACCIA
500 ft
Piazza Cola di Rienzo 83/A
Grotta Azzurra
700 ft
Via Cicerone 62a
Quelli del bar Cicerone
600 ft
Via Cicerone 68
Ristorante Visconti 2.0
800 ft
Via Ennio Quirino Visconti 83
Explore Rome
Local Highlights
Piazza Navona
16 minutes' walk
Famous for its stunning fountains and vibrant atmosphere. Perfect for a leisurely stroll or enjoying street performances.
Vatican Museums
20 minutes' walk
Home to world-renowned art, including the Sistine Chapel. Guided tours enhance your visiting experience.
Castel Sant'Angelo
13 minutes' walk
Historical fortress offering panoramic views of the city. Explore its museum and scenic surrounding area.
St. Peter's Basilica
20 minutes' walk
One of the largest churches in the world, known for its breathtaking architecture and art. Visit earlier to avoid crowds.
Bistro' 21
1 minute' walk
Charming bistro offering local Italian dishes. Cozy atmosphere, perfect for breakfast or a casual dinner.
Cantieri Bistrot
2 minutes' walk
Trendy eatery with seasonal ingredients. Enjoy creative dishes in a stylish setting. Reservations recommended.
Le Sicilianedde
1 minute' walk
Authentic Sicilian cuisine in a warm atmosphere. Known for their pasta and seafood dishes, catering to various diets.
La Pinseria Prati
1 minute' walk
Offers delicious Roman-style pinsa. Relaxed vibe with a variety of toppings. A must-try for pizza lovers.
Getting around
Looking for special rates when booking early?
Explore them with us!
Property information and rules
Check-in
from 15:00-23:59
Check-out
from 07:00-11:00
Guest Parking
Private parking is possible on site (reservation might be needed) at EUR 35 per day.
Internet
Wireless internet is available in for free.
Breakfast
The hotel Twentyone provides visitors with a free full breakfast.
Children & extra beds
There are no cots provided in a room.
Pets
Pets are not allowed.
Languages
English, German, Spanish, Italian, Russian, Moldovan
Year renovated:
2009
Number of floors:
6
Number of rooms:
88
Reviews and Ratings
Real comments from travelers who have already stayed
Show moreShow less
Pros
Perfect location
Friendly staff
Clean rooms
Cons
Outdated restaurant
Guest reviewsbased on 1390 reviews
Logan from United States
Single
double room
4 nights in November 2025
|
Reviewed:January 17, 2026
5/10
decent breakfastcramped roomsmall bathroom
the breakfast offered a decent start to the day (i liked the pastries).
unfortunately, the room felt quite cramped, and i found the bathroom to be small. the shower stall was narrow, and i struggled with the limited space. the bed also wasn't very comfortable.
0 Helpful
Isaac from United States
Single
Double Room
3 nights in November 2025
|
Reviewed:December 25, 2025
9/10
solid stay near vatican
vatican locationhelpful personnelluggage keeping
i appreciated the location near the Vatican. i enjoyed the breakfast. i found the personnel was helpful. the hotel kept my luggage after checkout.
0 Helpful
Georgia from United States
Family with children
Superior Double Room
4 nights in November 2025
|
Reviewed:December 01, 2025
5/10
a bit underwhelming for the price.
large stainnarrow door
The room was quite dark. Black furnishings and bed covers seemed to absorb all the light. there was also a rather large stain on one of the walls, which i found distracting and not very appealing. the narrow shower entrance made it a tight squeeze. I barely managed to get in. finally, the paper-thin walls meant i could hear everything from neighboring rooms, which disrupted my sleep
0 Helpful
Mary from United Kingdom
Single
double room
3 nights in November 2025
|
Reviewed:November 28, 2025
6/10
convenient locationfaulty air-conditioninginconvenient beds
the hotel location is convenient and close to many restaurants.
The room air-conditioning did not work properly and it was very hot, like a steam room. twin beds were not separated, quite inconvenient. i arrived early to leave my luggage, but the room was only ready at 3pm. I would have appreciated some flexibility.
0 Helpful
Ella from Australia
Single
Deluxe Double Room
4 nights in November 2025
|
Reviewed:November 27, 2025
9/10
Fantastic Hotel Experience
really good servicedelicious cappuccinofine city views
The staff provided really good service especially at breakfast I enjoyed the delicious cappuccino every morning The room was immaculate with fresh towels daily.
0 Helpful
timothy from united kingdom
Single
double room
3 nights in November 2025
|
Reviewed:November 25, 2025
7/10
balanced stay
helpful staffexcellent locationpoor air conditioninghard bed
the hotel location allowed easy walks to major attractions. the staff was courteous and helpful .
The room i booked did not match the description. the air conditioning was really poor. The bed was quite hard.
0 Helpful
FAQs
About Twentyone Hotel
How far is Twentyone Hotel from the Vatican?
The hotel is located 1 km from the Vatican and St. Peter's Basilica, which is a 15-minute walk away.
What popular attractions are near Twentyone Hotel?
Nearby attractions include Piazza Navona (1 km), Castel Sant'Angelo (1 km), and the Spanish Steps (2 km).
Does Twentyone Hotel offer parking facilities?
Private parking is available on-site for 35 EUR per day, and a reservation is needed.
What dining options are available at Twentyone Hotel?
The hotel features an on-site restaurant serving traditional Italian dishes and a Starbucks for breakfast.
Is breakfast included at Twentyone Hotel?
Breakfast is available for an additional charge of 15 EUR.
What amenities can guests expect in their rooms at Twentyone Hotel?
Rooms include air conditioning, an LCD TV, minibar, free Wi-Fi, and sound-proofed windows.
Does Twentyone Hotel provide fitness facilities?
Guests can access a fitness center during their stay.
Can I travel from the airport to Twentyone Hotel?
The hotel offers paid airport shuttle services for pickup and drop-off.
Is smoking allowed at Twentyone Hotel?
The hotel is a non-smoking establishment.
What is the distance from Twentyone Hotel to Roma Termini train station?
The hotel is located 2 km from Roma Termini train station.
How can I reach the hotel from Lepanto Metro Station?
Lepanto Metro Station is 450 metres from the hotel, approximately a 5-minute walk.
What is the location of Twentyone Hotel within Rome?
Twentyone Hotel is situated in the elegant Prati district, strategically located between the Vatican Museums and the Spanish Steps.
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