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Twentyone Hotel
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Welcome to Twentyone Hotel – Rome

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From82US$ /night
Check-in
25Oct2025Select date
Check-out
26Oct2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

Via Cola Di Rienzo 23, Rome, Italy, 00192

Twentyone Hotel is a 4-star boutique hotel located in Via Cola di Rienzo, one of the biggest shopping streets in Rome, halfway between the Vatican Museums and the Spanish Steps.

Designer Room Comforts

The rooms at Twentyone Hotel are elegant and perfect with custom-made designer furniture, LCD TV with satellite channels, free WiFi, minibar, and air-conditioning. Deluxe rooms on the fifth floor offer private terraces with views of St. Peter's Dome, while Junior Suites feature Jacuzzi tubs.

Italian Culinary Rotation

Bistrò 21 enhances Italian cuisine with daily rotating specialties: gnocchi on Monday, fish on Tuesday and Friday, meat on Thursday, and soup on Wednesday. The on-site restaurant serves traditional Roman dishes accompanied by a selection of wines and champagne.

Central Exploration Hub

Hotel Twenty One's strategic location allows easy access to museums, restaurants, and Rome's principal monuments. Guests can explore Villa Borghese, a large green area where Romans gather for walks, picnics, and outdoor relaxation.

Vatican-Adjacent Positioning

Located in the Prati district, Hotel Twenty One sits halfway between St. Peter's Basilica and Piazza di Spagna. The property is 300 meters from Lepanto subway station, providing convenient access to the Vatican, Piazza del Popolo, and famous shopping streets.

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Select your room type

Choose from doubles, suites, or family rooms, many with breakfast, flexible cancellation, and promotional rates
Twin Room
Twin Room
2 persons
18 m² 
2 Single beds
Shower
Heating
room details
Triple Room
Triple Room
2 persons
22 m² 
3 Single beds
Shower
Heating
room details
Double Room
Double Room
2 persons
18 m² 
1 King-size bed
Shower
Heating
room details
Deluxe Twin Room
Deluxe Twin Room
2 persons
23 m² 
2 Single beds
Shower
Heating
room details
Click button to see more rooms
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Price and Room Availability Calendar

Check availability and prices for your dates now!

Getting around

A guide to all available transportation options

City Centre
Rome 2.3 km
Airports
Ciampino (CIA) 18.6 km
Fiumicino (FCO) 29.6 km
Train
Roma San Pietro Train Station 1.9 km
Underground
Lepanto Metro Station400 m

Facilities

Boutique hotels design their amenities with your relaxation and unique travel experiences in mind
Free Wi-Fi
Parking

EUR 35 per day

Luggage storage
24-hour services

24-hour reception

General

  • Non-smoking rooms
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Allergy-free rooms
  • Lift
  • Barber shop
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre

Services

  • Paid airport shuttle
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business

  • Fax/Photocopying

Children

  • Cots
  • Children's buffet

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Garden area
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries
  • Sink

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Location

Via Cola Di Rienzo 23, Rome, Italy, 00192
Map view
Via Cola Di Rienzo 23, Rome, Italy, 00192
City landmarks
Fountain
Trevi Fountain
1.8 km
Church
Pantheon
1.6 km
Square
Colosseum
2.8 km
Landmark
Piazza Navona
1.3 km
Museum
Vatican Museums
1.6 km
Church
St. Peter's Basilica
1.8 km
Square
Saint Peter's Square
1.5 km
Landmark
Roman Forum
2.4 km
Landmark
Piazza di Spagna
1.4 km
Square
Spanish Steps
1.5 km
Bridge
Castel Sant'Angelo
1.1 km
Square
Piazza del Popolo
740 m
Square
Piazza Venezia
2.1 km
Church
Sistine Chapel
1.7 km
Cemetery
Altar of the Fatherland
2.2 km
Square
Campo de' Fiori
1.8 km
Landmark
Vatican City
1.8 km
Museum
Borghese Gallery and Museum
2.4 km
Bridge
St. Angelo Bridge
1.1 km
Landmark
Torre di San Giovanni
2.6 km
Church
Church of Saint Louis the French
1.4 km
Square
Largo di Torre Argentina
1.7 km
Church
Church of Santa Maria del Popolo
690 m
Zoo
Bioparco di Roma
2.0 km
Church
Santa Maria in Trastevere
2.2 km
Museum
Capitoline Museums
2.1 km
Square
Piazza Barberini
1.8 km
Museum
Museum of the Ara Pacis
900 m
Square
Pincian Hill
950 m
Church
Church of the Gesu
2.0 km
Nearby
Bridge
Castel Sant'Angelo
1.1 km
Square
Piazza del Popolo
740 m
Bridge
St. Angelo Bridge
1.1 km
Church
Church of Santa Maria del Popolo
690 m
Church
Basilica of Sant' Agostino
1.0 km
Restaurants
Bistro' 21
30 m
Via Cola di Rienzo 23 Hotel Twenty One
Cantieri Bistrot
90 m
Via Cola di Rienzo 16
Le Sicilianedde
80 m
Via Cola di Rienzo
La Pinseria Prati
80 m
Via Lucrezio Caro 60
Pasticceria Sanzini
130 m
Via Valadier
VINO e FOCACCIA
140 m
Piazza Cola di Rienzo 83/A
Grotta Azzurra
210 m
Via Cicerone 62a
Quelli del bar Cicerone
170 m
Via Cicerone 68
Ristorante Visconti 2.0
220 m
Via Ennio Quirino Visconti 83
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Check-in
25Oct2025Select date
Check-out
26Oct2025Select date
Rooms and Guests2 Guests, 1 Room
  • Overview
  • Rooms
  • Price calendar
  • Facilities
  • Location
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