Welcome to Twentyone Hotel – Rome

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From82US$ /night
Check-in
10Mar2026Select date
Check-out
11Mar2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

Via Cola Di Rienzo 23, Rome, Italy, 00192
-
Near the Vatican City
Great
8.3
8.1
/10
3.5
3.7
/5

Location

Hotel Twentyone is located in the Prati district, strategically situated between the Vatican and Piazza di Spagna. The hotel is within walking distance of landmarks such as the Vatican Museums, Trevi Fountain, and Castel Sant'Angelo. With the Lepanto underground station a mere 400 meters away, access to Rome's shopping and cultural sites is convenient.

Dining

Bistrò 21 offers a range of traditional Italian dishes crafted from top-quality ingredients. The restaurant provides lunch and dinner options, along with a buffet featuring fresh selections daily. Guests can enjoy a delightful aperitif with an ample buffet in a relaxed setting.

Rooms

The hotel comprises 93 rooms, each showcasing carefully curated decor and designer furnishings. Deluxe double rooms on the fifth floor provide private terraces with views of significant landmarks. Junior suites offer spacious comfort, complete with a Jacuzzi, ensuring a relaxing experience.

Family-Friendly Amenities

Families will appreciate connecting room options with two bathrooms, catering to various needs. Specific accommodations include triple rooms with flexible bed configurations. The hotel aims to provide convenience and comfort for families traveling with children.

Accessibility & Transportation

Rome's Termini train station is easily reachable via the A-line subway, providing quick access to the hotel. Additionally, Fiumicino and Ciampino airports connect the hotel conveniently to the city. The hotel's central location allows for easy exploration of Rome's iconic sites by foot or public transport.

Highlights

Location: halfway between the Vatican Museums and Piazza di Spagna .

Dining: Best traditional Italian dishes at Bistrò 21 .

Rooms: Deluxe double rooms with private terraces .

Family-Friendly: Two rooms connected by a door .

Must-do experiences

  • Sip espresso at Sant'Eustachio for the best in Rome.
  • Visit Basilica di San Clemente for layers of history.
  • Stroll through the Campo de' Fiori market for fresh produce.
  • Taste authentic Roman pizza at Pizzeria Da Baffetto.
  • Explore the Galleria Doria Pamphilj for stunning art collections.
View all

Select your room type

Choose from doubles, suites, or family rooms, many with breakfast, flexible cancellation, and promotional rates
Twin Room
2 persons
195 sq. feet 
2 Single beds
Shower
Heating
Triple Room
2 persons
240 sq. feet 
3 Single beds
Shower
Heating
Double Room
2 persons
195 sq. feet 
1 King-size bed
Shower
Heating
Deluxe Twin Room
2 persons
250 sq. feet 
2 Single beds
Shower
Heating
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Facilities

Boutique hotels design their amenities with your relaxation and unique travel experiences in mind
Facilities: Great
8.2/10Review score

General

  • Non-smoking rooms
  • Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Allergy-free rooms
  • Lift
  • Barber shop
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre

Services

  • Paid airport shuttle
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business

  • Fax/Photocopying

Children

  • Cots
  • Children's buffet

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Garden area
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries
  • Sink

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Dining Onsite

Vista is a modern dining haven at Twentyone Hotel, offering a delightful blend of international cuisines with an emphasis on traditional Roman and classic Italian flavors. The inviting atmosphere and rich buffet options create a welcoming space for leisurely meals or special gatherings.
Twentyone Hotel Rome Restaurant photo
Twentyone Hotel Rome Restaurant photo
Twentyone Hotel Rome Restaurant photo

Vista

International with Roman and Italian influences
Ambiance
Contemporary setting with a warm, inviting atmosphere, perfect for casual dining or special occasions.
Key Offerings
A delightful buffet filled with rich and tasty dishes, alongside an extensive selection of wines and champagne to complement the meal.
Reservation
Recommended
Open daily from 11:30 to 23:30

Twentyone Hotel Location

Via Cola Di Rienzo 23, Rome, Italy, 00192
Map view
Via Cola Di Rienzo 23, Rome, Italy, 00192
Nearby
Bridge
Castel Sant'Angelo
3500 ft
Square
Piazza del Popolo
2500 ft
Bridge
St. Angelo Bridge
3600 ft
Church
Church of Santa Maria del Popolo
2300 ft
Church
Basilica of Sant' Agostino
3400 ft
Restaurants
Bistro' 21
100 ft
Via Cola di Rienzo 23 Hotel Twenty One
Cantieri Bistrot
300 ft
Via Cola di Rienzo 16
Le Sicilianedde
300 ft
Via Cola di Rienzo
La Pinseria Prati
300 ft
Via Lucrezio Caro 60
Pasticceria Sanzini
500 ft
Via Valadier
VINO e FOCACCIA
500 ft
Piazza Cola di Rienzo 83/A
Grotta Azzurra
700 ft
Via Cicerone 62a
Quelli del bar Cicerone
600 ft
Via Cicerone 68
Ristorante Visconti 2.0
800 ft
Via Ennio Quirino Visconti 83
Explore Rome
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Piazza Navona
Piazza Navona
16 minutes' walk
Famous for its stunning fountains and vibrant atmosphere. Perfect for a leisurely stroll or enjoying street performances.
Vatican Museums
Vatican Museums
20 minutes' walk
Home to world-renowned art, including the Sistine Chapel. Guided tours enhance your visiting experience.
Castel Sant'Angelo
Castel Sant'Angelo
13 minutes' walk
Historical fortress offering panoramic views of the city. Explore its museum and scenic surrounding area.
St. Peter's Basilica
St. Peter's Basilica
20 minutes' walk
One of the largest churches in the world, known for its breathtaking architecture and art. Visit earlier to avoid crowds.
Biking along the Tiber
9 minutes' walk
Bike rental services available for a scenic ride along the Tiber River. Great for families and solo adventurers.
Yoga in the Park
18 minutes' walk
Relaxing yoga classes held in nearby parks. Ideal for unwinding amidst nature while enjoying Roman greenery.
Food Tours
15 minutes' walk
Explore local cuisines with guided food tours. Savor traditional dishes and learn about Roman culinary culture.
Thrilling Segway Tours
10 minutes' walk
Experience Rome in a unique way. Guided Segway tours navigate iconic sites, offering thrill-seekers an exciting perspective.
Bistro' 21
Bistro' 21
1 minute' walk
Charming bistro offering local Italian dishes. Cozy atmosphere, perfect for breakfast or a casual dinner.
Cantieri Bistrot
Cantieri Bistrot
2 minutes' walk
Trendy eatery with seasonal ingredients. Enjoy creative dishes in a stylish setting. Reservations recommended.
Le Sicilianedde
Le Sicilianedde
1 minute' walk
Authentic Sicilian cuisine in a warm atmosphere. Known for their pasta and seafood dishes, catering to various diets.
La Pinseria Prati
La Pinseria Prati
1 minute' walk
Offers delicious Roman-style pinsa. Relaxed vibe with a variety of toppings. A must-try for pizza lovers.
Piazza Navona Nightlife
16 minutes' walk
Vibrant area with street performances and open-air bars. Perfect for families and adults looking for a festive vibe.
Teatro dell'Opera di Roma
15 minutes' walk
Renowned theater offering opera and ballet performances. Check the schedule for family-friendly shows and tickets.
Live Music at Local Bars
10 minutes' walk
Enjoy live music at nearby venues showcasing local talent. Ideal for a fun night out with friends or a romantic evening.
Comedy Shows
10 minutes' walk
Weekly comedy nights guarantee laughs for all ages. A great option for a light-hearted evening near the hotel.
Getting around
City Centre
Rome28 min  ·  1.4 mi
Airports
Rome Ciampino Airport (CIA)28 min  ·  11.6 mi
Roma-Fiumicino Airport (FCO)45 min  ·  18.4 mi
Train
Flaminio Train Station10 min  ·  2700 ft
Underground
Lepanto Metro Station5 min  ·  1400 ft
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Property information and rules
Check-in
from 15:00-23:59
Check-out
from 07:00-11:00
Guest Parking
Private parking is possible on site (reservation might be needed) at EUR 35 per day.
Internet
Wireless internet is available in for free.
Breakfast
The hotel Twentyone provides visitors with a free full breakfast. 
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are not allowed.
Languages
English, German, Spanish, Italian, Russian, Moldovan
Year renovated:
2009
Number of floors:
6
Number of rooms:
88

Reviews and Ratings

Real comments from travelers who have already stayed
Review score
Based on 1343 verified reviews
8.0/10
Great
85%
Recommend
Breakfast
8.4/10
Cleanliness
8.6/10
Comfort
8.5/10
Facilities
8.2/10
Free Wi-Fi
8.1/10
Location
9.1/10
Paid Wi-Fi
7.9/10
Staff
8.7/10
Value for money
7.8/10
Pros
Perfect location
Friendly staff
Clean rooms
Cons
Outdated restaurant
Guest reviews
based on 1904 reviews
4/5
based on 3716 reviews
8.3/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
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FAQs
About Twentyone Hotel
What are the check-in and check-out times at Twentyone Hotel?
Check-in is from 15:00 and check-out is by 11:00.
How far is Twentyone Hotel from the Vatican?
The hotel is located 1 km from the Vatican and St. Peter's Basilica, which is a 15-minute walk away.
What popular attractions are near Twentyone Hotel?
Nearby attractions include Piazza Navona (1 km), Castel Sant'Angelo (1 km), and the Spanish Steps (2 km).
Does Twentyone Hotel offer parking facilities?
Private parking is available on-site for 35 EUR per day, and a reservation is needed.
What dining options are available at Twentyone Hotel?
The hotel features an on-site restaurant serving traditional Italian dishes and a Starbucks for breakfast.
Is breakfast included at Twentyone Hotel?
Breakfast is available for an additional charge of 15 EUR.
What amenities can guests expect in their rooms at Twentyone Hotel?
Rooms include air conditioning, an LCD TV, minibar, free Wi-Fi, and sound-proofed windows.
Does Twentyone Hotel provide fitness facilities?
Guests can access a fitness center during their stay.
Can I travel from the airport to Twentyone Hotel?
The hotel offers paid airport shuttle services for pickup and drop-off.
Is smoking allowed at Twentyone Hotel?
The hotel is a non-smoking establishment.
What is the distance from Twentyone Hotel to Roma Termini train station?
The hotel is located 2 km from Roma Termini train station.
How can I reach the hotel from Lepanto Metro Station?
Lepanto Metro Station is 450 metres from the hotel, approximately a 5-minute walk.
What is the location of Twentyone Hotel within Rome?
Twentyone Hotel is situated in the elegant Prati district, strategically located between the Vatican Museums and the Spanish Steps.

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Check-in
10Mar2026Select date
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Rooms and Guests2 Guests, 1 Room