Welcome to Twentyone Hotel – Rome

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From82US$ /night
Check-in
10Dec2025Select date
Check-out
11Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

Via Cola Di Rienzo 23, Rome, Italy, 00192
-
Near the Vatican City
Perfect
8.3
8.1
/10
3.6
3.7
/5

Location

Hotel Twentyone is situated in the Prati district, halfway between Vatican Museums and Piazza di Spagna. This strategic position allows guests to easily explore popular attractions like St Peter's Basilica and the Trevi Fountain on foot. The Lepanto underground station is only 400 meters away, providing quick access to Rome's fashionable shopping streets.

Rooms

The hotel offers 93 rooms designed with attention to detail and comfort. Deluxe double rooms, located on the fifth floor, include private terraces with views of the city's main monuments. Junior suites feature spacious layouts and Jacuzzis for added relaxation.

Dining

Bistrò 21 serves traditional Italian cuisine made with high-quality ingredients. Guests can enjoy a buffet lunch featuring a variety of Mediterranean dishes, available daily from 12 pm to 3 pm. The restaurant also offers an extensive selection of wines and a happy hour with custom cocktails.

Family Accommodations

The hotel provides family-friendly options with connected rooms featuring two bathrooms. The spacious layout allows for comfortable stays for parents and children. Special offerings, like kid-friendly menus at Bistrò 21, enhance the family experience.

Access and Transportation

Hotel Twentyone is easily accessible from Rome's Termini train station via the A-line subway. Both Fiumicino and Ciampino airports can be reached through convenient transport options. The hotel provides a central base for exploring the city's rich history and culture.

Highlights

Location: halfway between St Peter's and the Spanish Steps

Dining: Bistrò 21 with Mediterranean cuisine

Rooms: Deluxe double rooms with private terraces

Family: connected rooms for family stays

Must-do experiences

  • Sip espresso at Sant'Eustachio for the best in Rome.
  • Visit Basilica di San Clemente for layers of history.
  • Stroll through the Campo de' Fiori market for fresh produce.
  • Taste authentic Roman pizza at Pizzeria Da Baffetto.
  • Explore the Galleria Doria Pamphilj for stunning art collections.
View all

Select your room type

Choose from doubles, suites, or family rooms, many with breakfast, flexible cancellation, and promotional rates
Twin Room
2 persons
18 m² 
2 Single beds
Shower
Heating
Triple Room
2 persons
22 m² 
3 Single beds
Shower
Heating
Double Room
2 persons
18 m² 
1 King-size bed
Shower
Heating
Deluxe Twin Room
2 persons
23 m² 
2 Single beds
Shower
Heating
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Facilities

Boutique hotels design their amenities with your relaxation and unique travel experiences in mind

General

  • Non-smoking rooms
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Allergy-free rooms
  • Lift
  • Barber shop
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre

Services

  • Paid airport shuttle
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business

  • Fax/Photocopying

Children

  • Cots
  • Children's buffet

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Garden area
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries
  • Sink

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Dining Onsite

Vista is a modern dining haven at Twentyone Hotel, offering a delightful blend of international cuisines with an emphasis on traditional Roman and classic Italian flavors. The inviting atmosphere and rich buffet options create a welcoming space for leisurely meals or special gatherings.
Twentyone Hotel Rome Restaurant photo
Twentyone Hotel Rome Restaurant photo
Twentyone Hotel Rome Restaurant photo

Vista

International with Roman and Italian influences
Ambiance
Contemporary setting with a warm, inviting atmosphere, perfect for casual dining or special occasions.
Key Offerings
A delightful buffet filled with rich and tasty dishes, alongside an extensive selection of wines and champagne to complement the meal.
Reservation
Recommended
Open daily from 11:30 to 23:30

Location

Via Cola Di Rienzo 23, Rome, Italy, 00192
Map view
Via Cola Di Rienzo 23, Rome, Italy, 00192
Nearby
Bridge
Castel Sant'Angelo
1.1 km
Square
Piazza del Popolo
740 m
Bridge
St. Angelo Bridge
1.1 km
Church
Church of Santa Maria del Popolo
690 m
Church
Basilica of Sant' Agostino
1.0 km
Restaurants
Bistro' 21
30 m
Via Cola di Rienzo 23 Hotel Twenty One
Cantieri Bistrot
90 m
Via Cola di Rienzo 16
Le Sicilianedde
80 m
Via Cola di Rienzo
La Pinseria Prati
80 m
Via Lucrezio Caro 60
Pasticceria Sanzini
130 m
Via Valadier
VINO e FOCACCIA
140 m
Piazza Cola di Rienzo 83/A
Grotta Azzurra
210 m
Via Cicerone 62a
Quelli del bar Cicerone
170 m
Via Cicerone 68
Ristorante Visconti 2.0
220 m
Via Ennio Quirino Visconti 83
Explore Rome
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Piazza Navona
Piazza Navona
16 minutes' walk
Famous for its stunning fountains and vibrant atmosphere. Perfect for a leisurely stroll or enjoying street performances.
Vatican Museums
Vatican Museums
20 minutes' walk
Home to world-renowned art, including the Sistine Chapel. Guided tours enhance your visiting experience.
Castel Sant'Angelo
Castel Sant'Angelo
13 minutes' walk
Historical fortress offering panoramic views of the city. Explore its museum and scenic surrounding area.
St. Peter's Basilica
St. Peter's Basilica
20 minutes' walk
One of the largest churches in the world, known for its breathtaking architecture and art. Visit earlier to avoid crowds.
Biking along the Tiber
9 minutes' walk
Bike rental services available for a scenic ride along the Tiber River. Great for families and solo adventurers.
Yoga in the Park
18 minutes' walk
Relaxing yoga classes held in nearby parks. Ideal for unwinding amidst nature while enjoying Roman greenery.
Food Tours
15 minutes' walk
Explore local cuisines with guided food tours. Savor traditional dishes and learn about Roman culinary culture.
Thrilling Segway Tours
10 minutes' walk
Experience Rome in a unique way. Guided Segway tours navigate iconic sites, offering thrill-seekers an exciting perspective.
Bistro' 21
Bistro' 21
1 minute' walk
Charming bistro offering local Italian dishes. Cozy atmosphere, perfect for breakfast or a casual dinner.
Cantieri Bistrot
Cantieri Bistrot
2 minutes' walk
Trendy eatery with seasonal ingredients. Enjoy creative dishes in a stylish setting. Reservations recommended.
Le Sicilianedde
Le Sicilianedde
1 minute' walk
Authentic Sicilian cuisine in a warm atmosphere. Known for their pasta and seafood dishes, catering to various diets.
La Pinseria Prati
La Pinseria Prati
1 minute' walk
Offers delicious Roman-style pinsa. Relaxed vibe with a variety of toppings. A must-try for pizza lovers.
Piazza Navona Nightlife
16 minutes' walk
Vibrant area with street performances and open-air bars. Perfect for families and adults looking for a festive vibe.
Teatro dell'Opera di Roma
15 minutes' walk
Renowned theater offering opera and ballet performances. Check the schedule for family-friendly shows and tickets.
Live Music at Local Bars
10 minutes' walk
Enjoy live music at nearby venues showcasing local talent. Ideal for a fun night out with friends or a romantic evening.
Comedy Shows
10 minutes' walk
Weekly comedy nights guarantee laughs for all ages. A great option for a light-hearted evening near the hotel.
Getting around
City Centre
Rome28 min  ·  2.3 km
Airports
Ciampino (CIA)28 min  ·  18.6 km
Fiumicino (FCO)45 min  ·  29.6 km
Train
Roma San Pietro Train Station23 min  ·  1.9 km
Underground
Lepanto Metro Station5 min  ·  400 m
Looking for special rates when booking early?
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Property information and rules
Check-in
from 15:00-23:59
Check-out
from 07:00-11:00
Guest Parking
Private parking is possible on site (reservation might be needed) at EUR 35 per day.
Internet
is available in for free.
Breakfast
The hotel Twentyone provides visitors with a free full breakfast. 
Children & extra beds
There are no cots provided in a room. 
Pets
Pets are not allowed.
Languages
English, German, Spanish, Italian, Russian, Moldovan
Year renovated:
2009
Number of floors:
6
Number of rooms:
88
FAQs
About Twentyone Hotel
What are the check-in and check-out times at Twentyone Hotel?
Check-in is from 15:00 and check-out is by 11:00.
How far is Twentyone Hotel from the Vatican?
The hotel is located 1 km from the Vatican and St. Peter's Basilica, which is a 15-minute walk away.
What popular attractions are near Twentyone Hotel?
Nearby attractions include Piazza Navona (1 km), Castel Sant'Angelo (1 km), and the Spanish Steps (2 km).
Does Twentyone Hotel offer parking facilities?
Private parking is available on-site for 35 EUR per day, and a reservation is needed.
What dining options are available at Twentyone Hotel?
The hotel features an on-site restaurant serving traditional Italian dishes and a Starbucks for breakfast.
Is breakfast included at Twentyone Hotel?
Breakfast is available for an additional charge of 15 EUR.
What amenities can guests expect in their rooms at Twentyone Hotel?
Rooms include air conditioning, an LCD TV, minibar, free Wi-Fi, and sound-proofed windows.
Does Twentyone Hotel provide fitness facilities?
Guests can access a fitness center during their stay.
Can I travel from the airport to Twentyone Hotel?
The hotel offers paid airport shuttle services for pickup and drop-off.
Is smoking allowed at Twentyone Hotel?
The hotel is a non-smoking establishment.
What is the distance from Twentyone Hotel to Roma Termini train station?
The hotel is located 2 km from Roma Termini train station.
How can I reach the hotel from Lepanto Metro Station?
Lepanto Metro Station is 450 metres from the hotel, approximately a 5-minute walk.
What is the location of Twentyone Hotel within Rome?
Twentyone Hotel is situated in the elegant Prati district, strategically located between the Vatican Museums and the Spanish Steps.

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